A Novel Osmotic Pump Tablet Using Core of Drug-resin Complexes for Time-controlled Delivery System
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منابع مشابه
Novel osmotic pump tablet using core of drug-resin complexes for time-controlled delivery system.
A novel elementary osmotic pump tablet was developed. The system uses the core of drug-resin complexes (DRCs) loaded with propranolol hydrochloride (PNH) for time-controlled delivery. In traditional osmotic pump tablets (OPTs), the lag time was always minimized. However, in the DRCs osmotic pump tablet (DRCOPT), the lag time was increased to achieve the time-controlled delivery. The quantity of...
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Conventional drug delivery systems have little control over their drug release and almost no control over the effective concentration at the target site. The major problem associated with conventional drug delivery system is unpredictable plasma concentrations. Osmotic devices are the most promising strategy based systems for controlled drug delivery. They are the most reliable controlled drug ...
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Department of Pharmaceutics, Hindu College of Pharmacy, Guntur, Andhra Pradesh, India. _______________________________________________________________________ ABSTRACT Conventional drug delivery systems have slight control over their drug release and almost no control over the effective concentration at the target site. This kind of dosing pattern may result in constantly changing, unpredictabl...
متن کاملOsmotic drug delivery using swellable-core technology.
Swellable-core technology (SCT) formulations that used osmotic pressure and polymer swelling to deliver drugs to the GI tract in a reliable and reproducible manner were studied. The SCT formulations consisted of a core tablet containing the drug and a water-swellable component, and one or more delivery ports. The in vitro and in vivo performance of two model drugs, tenidap and sildenafil, formu...
متن کاملDevelopment of an osmotic pump system for controlled delivery of diclofenac sodium.
Based on an elementary osmotic pump, controlled release systems of diclofenac sodium (DS) were designed to deliver the drug in a zero-order release pattern. Osmotic pump tablets containing 100 mg DS were prepared and coated with either semipermeable (SPM) or microporous (PM) membranes. The tablet coats were composed of hydrophobic triacetin (TA) or hydrophilic polyethylene glycol 400 (PEG 400) ...
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ژورنال
عنوان ژورنال: YAKUGAKU ZASSHI
سال: 2008
ISSN: 0031-6903,1347-5231
DOI: 10.1248/yakushi.128.773